Seasonal Variation in The Frequency of Helicobacter Pylori Infection in Tobruk City, Libya
DOI:
https://doi.org/10.69667/lmj.2517114Keywords:
Helicobacter Pylori, Prevalence, Risk Factors, Season variation, Libya.Abstract
Helicobacter pylori (H, pylori) is one of the most common pathogenic bacteria infections that presents a substantial concern due to its link with gastric cancer and peptic ulcer. The infected individual usually does not exhibit clinical symptoms; therefore, it is important to understand the risk factors associated with the infection to diagnose and treat it early. Among these risk factors, the association between H pylori infection and season variation is not well understood. The aim of this study is to understanding the prevalence of h pylori infection in Tobruk City, eastern Libya, and its interaction with association factors such as gender, age, and the seasonality of H. pylori this in turn, may lead to a better understanding of other health phenomena such as the seasonal variation of peptic ulcers, that has remained an unresolved mystery for more than 90 years. 2551 samples were processed, using the TECAN Fecal H. pylori Antigen ELISA for the quantitative and qualitative detection of H. pylori antigen in feces. Results show that 33.6% of the cases were positive, and the percentage of infected females (34.1%) was insignificantly greater than that of infected males (32.9%). 34.1% were female and 32.9% were male. The results showed significant (X2= 22.52; P<0.001) association between H. pylori infection and age of the patient, in which the results explained that the highest percentage of infected patients for those aged < 10 years (39.3%) followed by those aged between 31-40 years (33.6%), The results revealed a significant (X2= 100.00; P<0.001) association between H. pylori infection and season of the year in which the highest rate of the infected patient was found during spring season (41.9%), followed by those patients infected during winter (28.1%) and summer (28.1%), however those patients infected during autumn were reported that lowest percentage (11.1%). Further prospective studies are highly recommended to provide further evidence and a clearer picture of H. pylori transmission
تعد الاصابه ببكتيريا البوابية الملتويه (الجرثومة الحلزونية )واحدة من أكثر أنواع العدوى البكتيرية الممرضة شيوعًا والتي تمثل مصدر قلق كبير بسبب ارتباطها بسرطان المعدة وقرحة المعدة. لا تظهر على الأفراد المصابين عادةً أعراض سريرية؛ لذلك، من المهم فهم عوامل الخطر المرتبطة بالعدوى لتشخيص العدوى وعلاجها في وقت مبكر. ومن بين هذه العوامل، فإن العلاقة بين عدوي البكتيريا االحلزونيه وتغيرات الموسم ليست مفهومة بشكل جيد. تهدف هذه الدراسة إلى فهم انتشار عدوى الحلزونيه في مدينة طبرق، شرق ليبيا وتفاعلها مع عوامل الارتباط مثل الجنس والعمر وموسمية لهذه البكتيريا، وهذا بدوره قد يؤدي إلى فهم أفضل لظواهر صحية أخرى مثل التباين الموسمي لقرحة المعدة، والتي ظلت لغزًا لم يتم حله لأكثر من 90 عامًا. تمت معالجة 2551 عينة باستخدام مستضد الملوية البوابية في البراز TECAN للكشف الكمي والنوعي عن مستضد الملوية البوابية في البراز. وأظهرت النتائج أن 33.6% من الحالات كانت إيجابية، وكانت نسبة الإناث المصابات (34.1%) أكبر بشكل طفيف من نسبة الذكور المصابين (32.9%). حيث كانت نسبة الإناث 34.1% والذكور 32.9%. وأظهرت النتائج ارتباطاً معنوياً (X2= 22.52؛ P<0.001) بين الإصابة بالجرثومة الحلزونية وعمر المريض، حيث أوضحت النتائج أن أعلى نسبة من المرضى المصابين كانت لمن هم أقل من 10 سنوات (39.3%) يليهم من هم في الفئة العمرية 31-40 سنة (33.6%)، كما كشفت النتائج عن وجود ارتباط معنوي (X2= 100.00؛ P<0.001) بين الإصابة بالجرثومة الحلزونية وموسم السنة حيث وجد أعلى معدل من المرضى المصابين خلال فصل الربيع (41.9%) يليه المرضى المصابين خلال فصل الشتاء (28.1%) والصيف (28.1%)، أما المرضى المصابين خلال فصل الخريف فقد سجلوا أقل نسبة (11.1%). ويوصى بشدة بإجراء المزيد من الدراسات المستقبلية لتوفير المزيد من الأدلة وصورة أكثر وضوحًا لانتقال بكتيريا البوابيه الملتويه
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