Serum Calcium to Magnesium Ratio in Preeclamptic Women: A Cross-Sectional Study

Abstract

Preeclampsia is a syndrome that adversely affects maternal and fetal outcomes. Despite extensive re-search, PE's exact pathogenesis is still uncertain. Micronutrients like calcium (Ca) and Magnesium (Mg) hemostasis were linked to many adverse health issues, including PE Herein, we aimed to verify the role of Calcium, Magnesium, and Calcium to Magnesium Ratio among PE cases vs. healthy controls for a possible application in preventive approach. The study enrolled 81 pregnant women whose age and body index matched and divided into two groups; PE cases and healthy controls. Their demographic, urine, and serum Calcium, Magnesium was compared. Analysis showed serum Ca2+ level, mean serum Ca2+-Mg2+ratio in the patients was considerably lower than in controls; P=0.01 and P=0.04, re-spectively. Reduced Mg levels were recorded only in PE cases. Correlation confirmed a positive cor-relation with maternal age and is inversely linked with gestational age, Ca 2+, Mg2+, and Ca2+-Mg2+ ratio. The diastolic blood pressure was negatively correlated to the Ca2+-Mg2+ ratio. Defining mi-cronutrients during pregnancy and how this may affect maternal health is a promising avenue for PE prevention. Micronutrient profiling might help characterize preeclampsia prevention options.