Histomorphometric Evaluation of Wormwood Effects on Cellular Activity: An In‑Vitro Experimental Study

Abstract

Artemisia absinthium L. (Asteraceae), commonly known as wormwood in the United Kingdom and absinthe in France, is an aromatic, perennial small shrub. It is locally known as ‘chajret mariem’ in Tunisia. The herb has always been of great botanical and pharmaceutical interest and is employed in folk medicine against various pains [11]. Wormwood essential oil has been widely used mainly for its neuroprotective, antifungal, antimicrobial, and antidepressant properties. This study aimed this study to explain the beneficial effect of wormwood on inflammation in the oral tissue after extraction. A total of 24adult male rats aged about 6 months and weighing about 250 g were divided into 2 groups. Group I (12rats) non diabetic. Group II (12 rats). The study group, were exposed to surgical wounds (extracted lower right first molar). They were sacrificed as follows: 4 rats from each group at intervals of 3 days, 7 days, and 21 days after extraction for histomorphometric study. In the present study, significant changes were observed in the mean number of active cells during the study period between 3 days and 7 days (p1 = 0.043) and no significant changes between 3 days and 21 days (p1 = 0.109). Whereas, no significant changes were observed in the mean number of active cells during the study period between 7 days and 21 days p2 (= 0.588). The current results demonstrate that Wormwood decreased the inflammatory signs leading to shortening of the healing time, which means that the wormwood has a well-known antiseptic property